The brain health and neuroscience bog Brain Posts has highlighted an interesting new research study that has combined low carb, high fat ketogenic dieting (for weight loss) and the Mediterranean diet (for maintenance) into a structured intervention for obese subjects with very positive results…
Antonio Paoli and colleagues from Italy and Greece conducted a clinical trial in obese subjects that included the following key components:
Subjects: 68 subjects with mean BMI >30 between 25 and 65 years of age without diabetes or other severe chronic illness
Diet intervention: One clinical trial with two cycles of 20 days of a very low carbohydrate diet (30 grams carbohydrate per day), 20 days of low carbohydrate diet (90 grams carbohydrate per day) separated by 4 and 6 month Mediterranean diet maintenance phases (260 grams carbohydrate per day). During carbohydrate restriction cycles, subjects received vitamin, mineral and herbal supplementation.
Measurements: Body weight, body fat, lipids, blood glucose, liver and kidney function and blood pressure
The results of clinical trial were pretty impressive. The average weight loss over 12 months was 16 kilograms or 35 pounds. That is an average 15% loss of body weight. Mean BMI dropped from 35.4 to 30.3. Mean percent body fat decreased from 43% to 34%.
Metabolic parameters improved with weight loss over the trial with mean total cholesterol dropping from 193 to 180, fasting glucose from 102 to 95. Mean blood pressure dropped from 125 to 118 systolic.
The authors note there is significant skepticism by medical professionals about very low carbohydrate diets. There is limited long-term efficacy and safety data. There were no serious adverse effects or deaths noted in the study from participation in the study. The completion rate was high suggesting subjects tolerated the trial.
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