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Research Suggests Low Carb Diet Is Best For Reducing Liver Fat

Published on February 26, 2014,

Diet Doctor Andreas Eenfeldt is reporting that a study is suggesting a low-carb diet is a good treatment for fatty liver. The research showed that in just six days on a low-carb diet, the reduction in the amount of liver fat was about the same as it was for seven monthson a calorie-restricted diet. Furthermore, the volume of the liver decreased quickly, probably because of less glycogen and fluids (decreased swelling)…

A Low-Carb Diet Best for Fatty LiverStudy after study shows a more effective weight loss on a low-carb diet. And if you reduce abdominal fat, you’re also reducing the amount of liver fat. The disease fatty liver is strongly associated with obesity and type 2 diabetes. Not surprisingly, yet another study* shows that a low-carb diet is a good treatment for fatty liver. In only six days on a low-carb diet, the reduction in the amount of liver fat was about the same as it was for seven months (!) on a calorie-restricted diet. Furthermore, the volume of the liver decreased quickly, probably because of less glycogen and fluids (decreased swelling). How do you most effectively decrease the amount of fat in your liver? In the same way that you melt fat off your abdomen. Less sugar and starch in your diet.

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See the research report here: Effects of dietary interventions on liver volume in humans.

Video: How A Low Carb Ketogenic Diet In Combination With Calorie And Protein Restriction Offers New Hope In Cancer Treatment

Published on July 10, 2013,

In a recent interview with Dr Mercola, leading cancer nutrition researcher Professor Thomas Seyfried discussed the benefits of a low carb, high fat, ketogenic diet for the treatment of cancer. Now Dr Mercola has published a follow-up interview with Dr Dominic D’Agostino, an assistant professor at the University of South Florida College of Medicine, looking at how a ketogenic diet combined with calorie restriction and hyperbaric treatment can offer new hope for a non-toxic cancer treatment…

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Some interesting observations from Dr D’Agostino include…

- A ketogenic diet that restricts glucose from cancer cells will harm them whereas healthy cells will be able to switch to obtaining energy from ketone bodies (you starve the cancer cells)

- Calorie restriction in combination with a ketogenic diet appears to offer enhanced benefits – and the ketogenic diet  makes the calorie restriction much easier – if you are eating a high fat, low carb diet you don’t feel so hungry and therefore are likely to eat less

- Protein also should be restricted as too much makes it hard to deplete the glycogen stores from the liver

- The combination of a carbohydrate restricted ketogenic diet, calorie restriction and protein restriction optimises the degree and sustainability of nutritional ketosis and enhances the impact on cancer

See more details and background on this from Dr Mercola at: Ketogenic Diet in Combination with Calorie Restriction and Hyperbaric Treatment Offer New Hope in Quest for Non-Toxic Cancer Treatment

Here’s the paper referred to by Dr D’Agostino: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer

Breakthrough: Scientists Find Compound Generated by Low Carb Ketogenic Diet Blocks Effects of Aging

Published on December 12, 2012,

Scientists at the Gladstone Institutes have identified a novel mechanism by which low-carb, low-calorie ketogenic diets could delay the effects of aging. This fundamental discovery reveals how such a diet could slow the aging process and may one day allow scientists to better treat or prevent age-related diseases, including heart disease, Alzheimer’s disease and many forms of cancer. This is from Gladstone Institutes…

As the aging population continues to grow, age-related illnesses have become increasingly common. Already in the United States, nearly one in six people are over the age of 65. Heart disease continues to be the nation’s number one killer, with cancer and Alzheimer’s close behind. Such diseases place tremendous strain on patients, families and our healthcare system. But today, researchers in the laboratory of Gladstone Senior Investigator Eric Verdin, MD, have identified the role that a chemical compound in the human body plays in the aging process—and which may be key to new therapies for treating or preventing a variety of age-related diseases.

In the latest issue of the journal Science, available online today, Dr. Verdin and his team examined the role of the compound β-hydroxybutyrate (βOHB), a so-called “ketone body” that is produced during a prolonged low-calorie or ketogenic diet. While ketone bodies such as βOHB can be toxic when present at very high concentrations in people with diseases such as Type I diabetes, Dr. Verdin and colleagues found that at lower concentrations, βOHB helps protect cells from “oxidative stress”—which occurs as certain molecules build to toxic levels in the body and contributes to the aging process.

“Over the years, studies have found that restricting calories slows aging and increases longevity—however the mechanism of this effect has remained elusive” Dr. Verdin said. Dr. Verdin, the paper’s senior author, directs the Center for HIV & Aging at Gladstone and is also a professor at the University of California, San Francisco, with which Gladstone is affiliated. “Here, we find that βOHB—the body’s major source of energy during exercise or fasting—blocks a class of enzymes that would otherwise promote oxidative stress, thus protecting cells from aging.”

Oxidative stress occurs as cells use oxygen to produce energy, but this activity also releases other potentially toxic molecules, known as free radicals. As cells age, they become less effective in clearing these free radicals—leading to cell damage, oxidative stress and the effects of aging.

However, Dr. Verdin and his team found that βOHB might actually help delay this process. In a series of laboratory experiments—first in human cells in a dish and then in tissues taken from mice—the team monitored the biochemical changes that occur when βOHB is administered during a chronic calorie-restricted diet. The researchers found that calorie restriction spurs βOHB production, which blocked the activity of a class of enzymes called histone deacetylases, or HDACs.

Normally HDACs keep a pair of genes, called Foxo3a and Mt2, switched off. But increased levels of βOHB block the HDACs from doing so, which by default activates the two genes. Once activated, these genes kick-start a process that helps cells resist oxidative stress. This discovery not only identifies a novel signaling role for βOHB, but it could also represent a way to slow the detrimental effects of aging in all cells of the body.

“This breakthrough also greatly advances our understanding of the underlying mechanism behind HDACs, which had already been known to be involved in aging and neurological disease,” said Gladstone Investigator Katerina Akassoglou, PhD, an expert in neurological diseases and one of the paper’s co-authors. “The findings could be relevant for a wide range of neurological conditions, such as Alzheimer’s, Parkinson’s, autism and traumatic brain injury—diseases that afflict millions and for which there are few treatment options.”

“Identifying βOHB as a link between caloric restriction and protection from oxidative stress opens up a variety of new avenues to researchers for combating disease,” said Tadahiro Shimazu, a Gladstone postdoctoral fellow and the paper’s lead author. “In the future, we will continue to explore the role of βOHB—especially how it affects the body’s other organs, such as the heart or brain—to confirm whether the compound’s protective effects can be applied throughout the body.”

More at:  Gladstone Scientists Discover Novel Mechanism by Which Calorie Restriction Influences Longevity

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